US Department of Defense
Advancing Blast Injury Research to Protect and Heal Those Who Serve

Simulating Traumatic Brain Injury In Vitro: Developing High Throughput Models to Test Biomaterial Based Therapies

Traumatic brain injuries are associated with some of the poorest outcomes in clinical practice. Such injuries can arise from blunt (closed) or penetrating trauma (open/pTBI). An injury track created by a foreign body (e.g. fragments or gunshot rounds) causes cavitation, shearing, and compression of nerve fibers and blood vessels, with damage to neurons and glia including myelin damage. The post-injury response mounted by multiple neural cell types includes microglial activation and astroglial scarring with the expression of a range of growth inhibitory molecules and cytokines in the lesion environment. For more information regarding this article, please read more here…


Basit RH, Wiseman J, Chowdhury F, Chari DM (2023). Simulating traumatic brain injury in vitro: developing high throughput models to test biomaterial-based therapies. Neural Regen Res 18(2):289-292.

Last modified: 21-Feb-2023