Wound infection continues to be a significant source of morbidity and mortality in the modern era of military healthcare. Victims of blast injury often suffer from multiple traumatic injuries; the mechanism, severity, and complexity of these injuries contribute to the risk for wound infection. Approximately one quarter of combat wounds become infected, which significantly impacts patient outcomes and healthcare costs. In response to this issue, the DoD Blast Injury Research Program Coordinating Office (PCO) organized the 2016 International State-of-the-Science (SoS) Meeting on "Minimizing the Impact of Wound Infections Following Blast-Related Injuries" in Arlington, Virginia on November 29 – December 1, 2016.
The meeting participants were charged with answering the following questions during the working group sessions:
Mr. Michael Leggieri, DoD Blast Injury Research Program Coordinating Office, welcomes participants to the 2016 International State-of-the-Science Meeting
Mr. Michael Leggieri, Director, DoD Blast Injury Research Program Coordinating Office, presents an overview of the meeting format and sets the goals and objectives
Dr. John Holcomb, University of Texas, in his keynote address, emphasizes the importance of wound infection diagnostics
Dr. John Holcomb, University of Texas; COL Kirby Gross, US Army Institute of Surgical Research; LCDR Matthew Bradley, Uniformed Services University of the Health Sciences; LTC Paige Waterman, Walter Reed Army Institute of Research (left to right) discuss and define the problem of wound infection during a Q&A session
Dr. Terry Rauch, Office of the Assistant Secretary of Defense � Health Affairs, discusses the impact of policy on wound infection prevention, prediction, and treatments
Dr. Michael Pucci, Spero Therapeutics (left) and COL Michael Kozar, US Army Medical Research and Materiel Command (right) discuss DoD and industry-sponsored research related to wound infection during a Q&A session
LTC Stuart Tyner, Walter Reed Army Institute of Research
Dr. Thomas Patterson, University of Texas Health Sciences Center at San Antonio, expert panelist
Dr. David Tribble, Uniformed Services University of the Health Sciences/Infectious Disease Clinical Research Program, expert panelist
Dr. Matt Aldag, Booz Allen Hamilton, summarizes the findings and conclusions from a recent literature review on wound infection
Dr. David Tribble, Uniformed Services University of the Health Sciences/Infectious Disease Clinical Research Program, presents ongoing work from the Trauma Infectious Disease Outcome Study (TIDOS) project
Dr. David Tribble, Uniformed Services University of the Health Sciences/Infectious Disease Clinical Research Program (left) and Dr. Matt Aldag, Booz Allen Hamilton (right) discuss the current state of the science during a Q&A session
COL Kirby Gross, US Army Institute of Surgical Research, expert panelist
COL Kirby Gross, US Army Institute of Surgical Research (left) and Dr. John Holcomb, University of Texas (right)
LTC Stuart Tyner, Walter Reed Army Institute of Research (WRAIR), provides an overview of ongoing initiatives and lines of effort within the WRAIR Wound Infections Department
MAJ Chad Black, Walter Reed Army Institute of Research, presents drug screening efforts supporting the Combating Antibiotic Resistant Bacteria (CARB) program
Dr. Anna Jacobs, Walter Reed Army Institute of Research, presents her work on developing bacteriophage as a treatment for multidrug resistant wound infections
Dr. Elena Barbu, Synthetic Genomics Vaccines, Inc., presents work on engineered bacteriophage treatments
Dr. Monique Van Hoek, George Mason University, discusses the use of novel peptides, inspired by the Komodo dragon, as a treatment for biofilms in infected wounds
Dr. Jennifer Neff, Allvivo Vascular, discusses the use of peptides to treat multidrug resistant biofilms
Dr. Daniel Kadouri, Rutgers School of Dental Medicine, discusses the use and effectiveness of predatory bacteria in controlling infection
Dr. Mark Smelterzer, University of Arkansas for Medical Sciences, discusses enhancing strategies for preventing and treating orthopaedic infections
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